Where does the pain come from? Most cases of back and neck pain are caused by nerve irritation from spinal joints that become locked or slightly misaligned due to muscle tightness, occupational stresses, prolonged standing, sitting, or from mild strain injuries, slips, falls, sports injuries, physical trauma, and foot problems. All of these factors lead to locked or misaligned spinal joints that irritate nerves and cause neck and back pain and also headache (...)